Gene Panels
Hematology DNA Panels
Interrogate clonal evolution of disease progression in hematologic malignancies that impact therapy response, resistance, relapse and residual disease. Identify rare subclones associated with remission and therapeutic resistance.
Acute Myeloid Leukemia ( AML Panel ): (20 Genes, 127 Amplicons) - Targeted NovaSeq 6000 150PE reads / sample - 75M
ASXL1
DNMT3A
EZH2
FLT3
GATA2
IDH1
IDH2
JAK2
KIT
KRAS
NPM1
NRAS
PTPN11
RUNX1
SF3B1
SRSF2
SP53
U2AF1
WT1
TET2
Myeloid Panel: (45 Genes, 312 Amplicons) - Targeted NovaSeq 6000 150PE reads / sample - 190M
ASXL1
ATM
BCOR
BRAF
CALR
CBL
CHEK2
CSF3R
DNMT3A
ERG
ETV6
EZH2
FLT3
GATA2
GNAS
IDH1
IDH2
JAK2
KDM6A
KIT
KMT2A
KRAS
MPL
MYC
MYD88
NF1
NPM1
NRAS
PHF6
PPM1D
PTEN
PTPN11
RAD21
RUNX1
SETBP1
SF3B1
SMC1A
SMC3
STAG2
STAT3
TET2
TP53
U2AF1
WTI
ZRSR2
Chronic Lymphocytic Leukemia (CLL Panel) : (32 Genes, 274 Amplicons) - Targeted NovaSeq 6000 150PE reads / sample - 165M
ATM
BCOR
BIRC3
BRAF
BTK
CARD11
CD79B
CHD2
CREBBP
CXCR4
DDX3X
EGR2
EZH2
FAT1
FBXW7
KRAS
LRP1B
MAP2K1
MED12
MYD88
NFKBIE
NTOCH1
NRAS
PLCG2
POT1
RPS15
SETD2
SF3B1
SPEN
TP53
XPO1
ZMYM3
Solid Tumor DNA Panel
High resolution of genomic diversity by interrogating targeted regions in oncogenes and tumor suppressors.
Tumor Hotspot (THP) Panel: (59 Genes, 244 Amplicons) - Targeted NovaSeq 6000 150PE reads / sample - 150M
ABL1
AKT1
ALK
APC
AR
ATM
BRAF
CDH1
CDK4
CDKN2A
CSF1R
CTNNB1
DDR2
EGRF
ERBB2
ERBB3
ERBB4
ESR1
EZH2
FBXW7
FGFR1
FGFR2
FGFR3
FLT3
GNA11
GNAQ
GNAS
HNF1A
HRAS
IDH1
IDH2
JAK1
JAK2
JAK3
KDR
KIT
KRAS
MAP2K1
MAP2K2
MET
MLH1
MPL
MTOR
NOTCH1
NRAS
PDGFRA
PI3KCA
PTEN
PTPN11
RAF1
RB1
RET
SMAD4
SMARCB1
SMO
SRC
STK11
TP53
VHL
Custom DNA Panels
Tapestri Designer Software allows custom tailoring of DNA panels to target the relevant genomic regions of heterogeniety for your research. Primer design is optimized for the Tapestri Platform to provide high design coverage and panel uniformity.
Mission Bio Sample Preparation Links
- Sample Preparation FAQs
- Nuclei Extraction from Frozen Tissue User Guide
- Video - Tapestri Instrument / Technology
Mission Bio Tapestri - Data Analysis Software Links
- Tapestri Insights Analysis Software
- Video - Tapestri Insights Analysis Software Demo
- Tapestri Portal - Single location to access MissionBio software tools and collateral materials.
- Tapestri Pipeline - Processing DNA +protein sequencing data.
- Tapestri Insights - Visualize variants and subclones to revel clonal heterogeneity.
- Developer Tools - Access to Mosaic : tools to analyze DNA and protein data for tertiary analysis.